#linear encoders market structure

[fatehbaz]

In the ruins, ‘master narratives of history as progress decompose into the tense confabulations of a continuously remembered past that hits the present like a nervous shock’ [...]. The ghosts of this past rear up in the ruin, they are the debris of unprecedented material destruction [...] ‘the “trash” of history’ [...]. Forgetting this carnage [would be to support] the myth of [...] progress [...]. But the ruins remember [...], revealing the fragility of the social order. [...] Hauntings rupture linear temporality, inconveniently bring forth energies, which have supposedly been extinguished and forgotten. [...] Cities [and places, generally] seem to becoming increasingly regulated. In the transformation towards a service economy during the 1980s [in Britain], [...] [o]ld industrial sites were turned into shopping centres, retails parks and leisure sites. [...] There is then, in the drive to market places, [...] an aesthetic imperative to smooth over the cracks [...], and to fix the past, so that it does not intrude into an imagined linear future. [...] In cahoots with [...] marketeers, they suggest that the past is a distant, romantic echo that resounds faintly in museums [...]. Yet the ruins shout back at the refurbished urban text. [...] [T]hey haunt the city, for the unofficial past cannot be exorcised [...]. Ruins are sites where we can construct alternative stories to decentre commodified, official [...] descriptions, and [...] keep the past opened [...]. Counter-memories can be articulated in ruins, narratives that talk back to the smoothing over of difference. Away from the commercial and bureaucratic spaces of the city, ghosts proliferate where order diminishes. Ruins are [...] especially important, because [...] it is ‘essential to see the things and the people who are primarily unseen and banished to the periphery of our social graciousness.’

Text above by: Tim Edensor. “Haunting in the ruins: matter and immateriality.” Space and Culture Issue 11, pages 42-50. January 2002. [Bold emphasis added by me.]

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[T]he contemporary Western city [...] [is] the site of [...] regulatory regimes concerned with strategies of surveillance and aesthetic monitoring [...]. The modern city can never become a wholly Appollonian, seamlessly regulated realm for it continues to be haunted by the neglected, the disposed of, and the repressed [...]. Within the interstices of the city there are a host of other spaces, part of a “wild zone”, a “[…] site […] which avoids the objective processes of ordered territorialisation […]”.

Staged […] through the intensified mediatisation and commodification of popular sites, myths, and icons […], mediated imaginary geographies circulate through adverts, soap operas, ‘classic’ rock stations [...] typically drenched in […] ideologies. […] These exhibitions memorialise culture via ‘publicly sanctioned narratives’ and institutionalised rhetoric [...]. [I]n which people are encoded and contextualied, categorised and narrated.

Accordingly, ruins are places from which other memories can be articulated [...]. [T]he outmoded object can become charged [...] with a certain power, and "might spark a brief profane illumination of a past productive mode, social formation, and structure of feeling - an uncanny return of a historically repressed moment" [...]. Thus we might stumble across seemingly archaic decor or furniture, [...] toys, and mascots of yesteryear [...], the debris of discarded fashions [...]. Although such objects [may] seem [...] absurd or comical, they may bring back knowledge, tastes, and sensations [...]. This was debris which was enfolded into the mundaneity of a shared everyday [...].

Along with other places on the margins of regulated space, industrial ruins are “points of transition, passages [...], moments of magic that exist at the interstices of modernity” […]. Modern attempts to cleanse, banish ambiguity, and order the memory of space are always disturbed by such disorderly spaces and by the ghosts they contain, who refuse to rest quietly, [...] a “spectral [...] residue“ which haunts dominant ways of seeing and being [...].

In contradistinction to the fixed memories [...] and to the imaginary linearities proposed by hegemonic […] memories, these ghosts foreground ambiguity, polysemy, and multiplicity, enabling us to “disrupt the signifying chains of legitimacy [...].” Although it is often overcoded and regulated, the city nevertheless contains multitudinous scraps from which alternative stories might be assembled. […] In spaces such as industrial ruins, the excessive debris confronted constitutes material for multiple modes of narration about the past: “the debris of shipwrecked histories still today raise up the ruins of an unknown, strange city. They burst forth within the modernist, massive, homogenous city like slips of the tongue from an unknown, perhaps unconscious, language” [...].

This kind of remembering implies an ethics about confronting and understanding otherness (here, the alterity of the past) which is tactile, imaginative […].

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Text by: Tim Edensor. “The ghosts of industrial ruins: ordering and disordering memory in excessive space.” Environment and Planning D: Society and Space Volume 23, pages 829-849. 2005. [Bold emphasis and some paragraph breaks/contractions added by me.]

[aidc-india]

Barcode Definitions 101 | Uses & Guide | AIDC INDIA – 2025

Barcodes play a vital role in today’s business environment. From retail checkout systems to inventory tracking, they have transformed the way data is collected and managed. As we step into 2025, it becomes more important to understand barcode definitions and their role in modern operations. This guide from AIDC Technologies India is designed to simplify everything you need to know about barcodes and their practical uses.

2. What Is a Barcode? A Simple Definition Explained

A barcode is a machine-readable code represented as numbers and parallel lines or squares. Barcode definitions explain how this code is structured and what type of data it holds. Barcodes typically encode product information like SKU, batch number, or manufacturing details. They are scanned using barcode readers, which instantly convert visual patterns into digital data.

3. Types of Barcodes Used in 2025

There are various types of barcodes in use, each with its own format and function. Barcode definitions help identify which format suits a particular industry or task:

1D Barcodes: These are linear barcodes like UPC, EAN, and Code 128, often used in retail and inventory.

2D Barcodes: These include QR codes and Data Matrix codes, used for storing more complex data.

PDF417: A stacked linear barcode used on IDs and transport documents.

Each format has a specific barcode definition and is designed to meet unique requirements based on space, readability, and data needs.

4. How Barcodes Work: From Scanning to Data Collection

The basic process begins with printing a barcode on a label or product. A barcode scanner reads the lines or squares, and decoding software extracts the stored information. Barcode definitions help determine what type of scanner and software are needed to read the code accurately. This simple process eliminates manual entry and ensures fast, reliable data capture across operations.

5. Key Uses of Barcodes in Modern Industries

Barcode definitions are foundational in a wide range of sectors. In retail, barcodes are used for pricing and checkout. In warehouses, they track stock movement and inventory levels. Healthcare uses barcodes for labeling medicine and managing patient records. Logistics companies depend on barcodes for real-time tracking of shipments. The correct use of barcode definitions ensures that the data captured is accurate and usable.

6. AIDC India’s Role in Barcode Solutions

AIDC Technologies India provides complete barcode systems—from labels and scanners to printers and integration software. Our deep understanding of barcode definitions allows us to recommend the right type of barcode solution for your specific industry. We support clients in retail, manufacturing, healthcare, education, and logistics with customized systems that improve data tracking and minimize errors.

7. Benefits of Using Barcodes in Business

Barcodes offer several benefits that go beyond just automation. Proper use of barcode definitions brings improvements in many business areas:

Speed: Barcodes speed up scanning and reduce checkout time.

Accuracy: Minimizes manual errors in data entry.

Inventory Control: Keeps track of stock movement in real time.

Cost Savings: Reduces labor and improves efficiency.

By applying the right barcode definitions, businesses can unlock these advantages more effectively.

8. Barcode Definitions vs QR Codes vs RFID

Understanding how barcode definitions compare to other technologies helps in selecting the best system. Barcodes are simpler and more cost-effective for small to medium-sized operations. QR codes, which are 2D barcodes, can store more data and are often used in mobile marketing or payment systems. RFID, which uses radio waves, allows item tracking without line-of-sight scanning. However, barcode systems remain more accessible and easier to implement.

9. Smart Barcode Scanning Solutions by AIDC India

AIDC India offers barcode scanning devices that are optimized to read all standard barcode definitions. Whether it’s a handheld scanner for retail or an industrial-grade scanner for warehouses, our devices ensure fast, accurate, and error-free data collection. We also provide software tools that integrate these scanners with your inventory or billing systems for seamless workflows.

10. Choosing the Right Barcode System for Your Business

Barcode definitions help businesses choose the right format, printing method, and scanning tools. AIDC India helps you evaluate your operational needs, the volume of data you need to encode, and the environment where scanning takes place. Based on these factors, we recommend and implement barcode systems that align with your goals.

11. Future of Barcodes: Trends to Watch in 2025

As we look ahead, barcode definitions are evolving with technology. Mobile barcode scanning is becoming more popular, especially in e-commerce and delivery services. Smart inventory systems are using AI to analyze barcode data for forecasting and planning. Environment-friendly printing solutions are also emerging. AIDC India stays updated with these trends to provide future-ready barcode solutions for businesses of all sizes.

12. Get Started with Barcode Solutions from AIDC India

Barcodes are a small but powerful part of your business infrastructure. With the right barcode definitions and tools, you can automate operations, reduce costs, and improve customer satisfaction. AIDC Technologies India offers everything you need—from barcode labels and printers to scanners and integration support.

Call to Action: Ready to streamline your operations with smart barcode solutions? Contact AIDC Technologies India today for a free consultation, customized recommendations, and reliable tools that match your business goals.

[globalgrowthinsights]

Laminated Particle Boards Market Size, Share, Forecast [2032]

Laminated Particle Boards Market provides in-depth analysis of the market state of Laminated Particle Boards manufacturers, including best facts and figures, overview, definition, SWOT analysis, expert opinions, and the most current global developments. The research also calculates market size, price, revenue, cost structure, gross margin, sales, and market share, as well as forecasts and growth rates. The report assists in determining the revenue earned by the selling of this report and technology across different application areas.

Geographically, this report is segmented into several key regions, with sales, revenue, market share and growth Rate of Laminated Particle Boards in these regions till the forecast period

North America

Middle East and Africa

Asia-Pacific

South America

Europe

Key Attentions of Laminated Particle Boards Market Report:

The report offers a comprehensive and broad perspective on the global Laminated Particle Boards Market.

The market statistics represented in different Laminated Particle Boards segments offers complete industry picture.

Market growth drivers, challenges affecting the development of Laminated Particle Boards are analyzed in detail.

The report will help in the analysis of major competitive market scenario, market dynamics of Laminated Particle Boards.

Major stakeholders, key companies Laminated Particle Boards, investment feasibility and new market entrants study is offered.

Development scope of Laminated Particle Boards in each market segment is covered in this report. The macro and micro-economic factors affecting the Laminated Particle Boards Market

Advancement is elaborated in this report. The upstream and downstream components of Laminated Particle Boards and a comprehensive value chain are explained.

Browse More Details On This Report at @https://www.globalgrowthinsights.com/market-reports/laminated-particle-boards-market-100568

 Global Growth Insights

Web: https://www.globalgrowthinsights.com

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[kuoxen]

A Brief Introduction To Diffusion Models

Demos

Applications

Image Editor: Photoship plugins like

Effects in Shorts https://youtube.com/shorts/uW13BzNcy-k?feature=share

Music generation: Riffusion

Video Generation(very early stage)

Marketing

Creator Marketing tools

And lots went to NSFW(especially with the leaked models from NovalAI which specialized in animation)

Players

OpenAI: DELL-E/DALL-E 2

Google: Imagen: Text-to-Image Diffusion Models

Meta: Make-A-Scene

Microsoft: NUWA-Infinity

Midjourney

And other Stable Diffusiion powered start-ups

Generating Images: Variational Diffusion Models

What is generation

Given observed samples x from a distribution of interest, the goal of a generative model is to learn to model its true data distribution p(x). Once learned, we can generate new samples from our approximate model at will

Variational Autoencoders

Incorporate latent variables: we can think of the data we observe as represented or generated by an associated unseen latent variable, which we can denote by random variable z.

And how to approximate : Evidence Lower Bound (ELBO)

Hierarchical Variational Autoencoders

Variational Diffusion Models

HVAE with Properties

The latent dimension is exactly equal to the data dimension

The structure of the latent encoder at each timestep is not learned; it is pre-defined as a linear Gaussian model. In other words, it is a Gaussian distribution centered around the output of the previous timestep

The Gaussian parameters of the latent encoders vary over time in such a way that the distribution of the latent at final timestep T is a standard Gaussian

Workflow in a nutshell

Three equivalent objectives to optimize a VDM( derived from ELBO in the appendix,reparameterization trick and VDM's properties)

Learning a neural network to predict the original image x0

Learning a neural network to predict the source noise ε0 (empirically, some works have found this resulted in better performance)

Learning a neural network to predict the score of the image at an arbitrary noise level ∇logp(xt)

How it works then

The basic architecture

The learning and inference process

Other details

The weighting of the training obj for different timesteps

Noise schedule

Trilemma and Variants

Advanced Forward Process

Parameterize the diffusion process, like αt

Non-Markovian diffusion process and denoising process

Momentum-based diffusion

Advanced Reverse Process

Conditional GANs

Advanced Models

Progressive Distillation

Stable Diffusion: lowered the cost, made it consumer-level and popular

Generating Images Under Guidance

A naive way is to add the guidance in the reverse process

Image conditioning: channel-wise concatenation

Text conditioning

Single vector embedding: spatial addition / adaptive group norm

Seq of vector embeddings: attention

Caveat: VDM may potentially learn to ignore or downplay any given conditioning information

Guidance : explicitly control the amount of weight the model gives to the conditioning information, at the cost of sample diversity

Classifier Guidance

Classifier-free Guidance

Cascaded Generation

Subject-Driven Generation

DreamBooth

Background

Approach

Results

Appendix

Understanding Diffusion Models- A Unified Perspective.pdf

TACKLING THE GENERATIVE LEARNING TRILEMMA WITH DENOISING DIFFUSION GANS

Tutorial on Denoising Diffusion-based Generative Modeling: Foundations and Applications

What are Diffusion Models?

DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven GenerationA Brief Introduction To Diffusion Models

Frechet inception distance (FID) and Inception Score (IS) for evaluating sample fidelity

For sample diversity, use the improved recall score

For sampling time, we use the number of function evaluations (NFE) and the clock time when generating a batch of 100 images on a V100 GPU.

ELBO of VDM:

[sondelete3]

The Function Of Hydrolysed Proteins

Get Sarms Uk

Content

Biotech & Biochem Research Items

Bioactive Healthy Protein As Well As Peptides Market Gamers, Dimension, Cagr, Applications, Kinds, Analysis, Fads, Forecast To 2027.

Cardarine Gw.

Unquenched Calibration Peptide For Snaptide ® 521. Vamptide ® Peptide Substrate (o.

Typical applications for these identified peptides consist of the Fluorescence (or Förster) Resonance Power Transfer analysis of receptor-ligand interactions, protein-protein interactions and also the cleavage of substratum molecules. An unique antifungal bicyclic peptide from the aquatic sponge Theonella generates development of vacuoles and overflow of 1, 3-beta-D-glucan. Theonellamide F inhibits development of numerous pathogenic fungi and has cytotoxic properties versus L1210 as well as P388 leukaemia cells. It can be utilized as essential biomarker for the measurement of antigens and also as a non-invasive method for discovering intrusive fungal infections. These can triggering injury and illness when touching body cells, as they engage with biomolecules such as enzymes, hormones and mobile receptors. Toxins vary substantially in their extent, ranging from normally minor or acute responses to fatality. There are several ways to generate powerful bicyclic peptides, one of the most usual being phage-encoded libraries.

In expert facilities, utilizing B-type natriuretic peptide blood degrees to guide treatment in people with persistent heart failure shows pledge however did not improve survival for all groups. In this review, the advantage was just seen in patients aged much less than 75, who made it through an added 1.5 years on average, and potentially those with bad heart feature.

Biotech & Biochem Research Study Items

Using this procedure a single linear peptide substratum will certainly yield a distinct collection of customized cyclic peptides (5 in the instance shown in Fig. 2), each with a distinct conformation, and a variety of target binding and also physicochemical residential or commercial properties. In all present-day microorganisms, details inscribed in DNA, the hereditary material of the cell, is converted via an RNA intermediate right into proteins, the molecular makers of the cell. Nevertheless, proof recommends that in a remote transformative previous our single-celled forefathers made use of just RNA for both genetic info storage space and metabolism. A foundation of this "RNA world" would certainly have been an RNA able to replicate itself.

Dispute Over Muscle-Building Drugs Goes to Court - Wall Street Journal

Dispute Over Muscle-Building Drugs Goes to Court.

Posted: Thu, 12 Oct 2017 07:00:00 GMT [source]

The Swiss based Bachem Team is a public, innovation-driven company concentrating on the development and also manufacturing of pepTides and oligonucleoTides. As a complete supplier Bachem uses items for clinical growth and business applications along with a thorough directory as well as unique custom synthesis.

Bioactive Healthy Protein As Well As Peptides Market Players, Dimension, Cagr, Applications, Kinds, Analysis, Trends, Forecast To 2027.

Now-a-days, it is obtaining changed with solid-phase synthesis due to its simplicity as contrasted to the former. However, fluid stage synthesis remains valuable in the large production of peptides for commercial objectives. To seek a peptide mimetic, it is very vital to determine a peptide or a peptide sequence within the target protein that is taken into consideration for the assay. Structural restrictions are considered to seek the legitimacy of the functions.

Bicycles can be conveniently determined to drug a vast range of targets and target classes, including lots of that have actually until now been undruggable with little particles, such as protein-protein interactions. This screening procedure self-selects for Bicycles that are amenable to add-on-- frequently described as conjugation-- to other molecular hauls such as cytotoxins, natural immune activators or other Bikes. Bikes can be connected with each other with artificial ease to produce complex molecules with combinatorial pharmacology. Alternatively, Bikes in the form of multimers can additionally be used as standalone therapeutics, including those that we are discovering in our T-cell modulator program. Our team believe that the versatility of our Bicycles as well as our effective testing platform allow brand-new therapies to be quickly developed and also lowered to exercise to potentially serve varied restorative applications throughout a variety of indicators.

Cardarine Gw.

Bicyclic peptides such as the amatoxins and phalloidin contain a connecting team, typically in between two of the side chains. There are a variety of cyclic peptide hormones that are cyclised through a disulfide bond between two cysteines-- for instance, somatostatin as well as oxytocin.

Does MK 677 increase testosterone?

MK-677 treatment reduced serum total testosterone (P

Rosario is an Elderly Scientist at the Medicinal Chemistry Institute (IQM-CSIC), Madrid. She is associated with peptides, additional framework mimics as well as small-molecule peptidomimetics of application in biological/medicinal chemistry programs, especially pertaining to the modulation of ion networks and associated proteins. The initial professional tests of Modi-1, the lead candidate from the Moditiope ® system, are anticipated to target people with triple unfavorable bust cancer cells, ovarian cancer cells as well as osteosarcoma. To utilize the wide applicability of Bicycles, we have actually participated in several collaborations beyond our inner focus in oncology. These calculated collaborations, each with partners that have deep restorative know-how, are based upon the wide applicability of the proprietary Bike platform and its capacity to deal with a wide variety of targets. These partnerships improve our ability to bring this crucial class of medicines to clients with devastating conditions besides cancer.

Unquenched Calibration Peptide For Snaptide ® 521. Vamptide ® Peptide Substratum (o.

Phage approaches have been established for illness targets as well as the generation of powerful phage complied with by cyclisation of the phage-encoded linear peptides including three cysteine residues. The method was efficiently used on human plasma kallikrein inhibitors generated with nanomolar affinities. Depsipeptides are peptides in which one of the amide linkages is replaced by a lactone link. Some cyclic as well as bicyclic depsipeptides are cyclised between the C-terminal carboxyl as well as the side chain of a threonine or serine deposit.

In studies of trained as well as untrained mice, Cardarine triggered fast twitch muscular tissue fiber to convert to slow down jerk muscular tissue fibers.

Where Cardarine or GW50515 becomes very fascinating is that PPARD activation raised mitochondrial biogenesis in the muscular tissue, which can renovate your muscle cells!

At simply 1mg per day for 3 weeks a professional trial showed an average gain of 1.21 kg in LBM which is virtually 1 extra pound of LBM weekly which is definitely crazy thinking about the time frame as well as the reality that they were not even training.

Because of this Cardarine is typically called a workout mimetic as only workout could normally make these adjustments to your metabolic rate and also fiber composition.

The typical results from this are 7-10lbs of LBM, good increases in strength and little to lean loss.

The typical dose for performance enhancement is 2-10mg daily for 4-8 weeks.

The survival of these markers in historical bones was examined using a collection of 26 ovicaprid specimens from Domuztepe, a Neolithic site in south main Turkey. These pens were used to examine the osteological decision of 24 of the Domuztepe bones, and determine the varieties for 2 immature specimens. The collagen-peptide technique has advantages over other non-morphological approaches of sheep/goat difference because of the long-term survival of collagen over other biomolecules such as ancient DNA. The outcomes additionally highlighted the problems in trusting one morphological standard, in this instance on the distal span, to compare lamb and goat bones.

Our screening platform can be released to evaluate either soluble healthy proteins or cell-based targets. Along with being resource-efficient and also rapid, the process distinctly utilizes an essential on-phage binding assay that notifies structure activity connections. We can include a broad series of tiny particle scaffolds into Bicycles to raise diversity as well as provide differentiated physicochemical as well as structural buildings. , Methods to improve plasma fifty percent life time of peptide and also healthy protein medicines, Amino Acids, 2006, 30, 351-- 367 CrossRef CAS PubMed. , Testimonial cyclic peptides on a merry-go-round; towards medicine style, Biopolymers, 2015, 104, 453-- 461 CrossRef CAS PubMed. , Impact of cumbersome side chains of amino acids on the option conformation of peptide fragment (81-92) derivatives of CD4, TYICEVEDQKEE, as researched by NMR spectroscopy as well as molecular modeling, Biochim. , Constraining cyclic peptides to simulate protein framework motifs, Angew.

BPC157 Ireland ='display: block;margin-left:auto;margin-right:auto;' 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" width="309px" alt="Sarms advantages"/>

Nonetheless, there was a reduction in hospital admissions for heart failure for everyone. information BPC157 Poland got his PhD in Immunology at the University of Tuebingen. He has actually established the modern technology system XPRESIDENT, which incorporates techniques from peptidomics, genomics and immunology in order to discover unique and also naturally presented cancer antigens. The system is commercialised by immatics biotechnologies, where Toni Weinschenk, likewise a founder of the company, is heading the drug discovery team. Using a hydrolysed protein can assist to decrease GI and/or skin-related indications as the hydrolysed healthy protein is unable to crosslink receptors on pole cells, as a result minimising degranulation as well as launch of histamine. Bradykinin is an inflammatory mediator and an important regulator of blood pressure, kidney feature as well as heart feature, as well as likewise involved in swelling.

By modifying the amino acid sequence we can regulate whether these peptides set up into hydrogels composed of nanofibers or peptide nanotube structures. We have developed our own internal modern technology to allow for the post-folding labelling of little healthy proteins. This approach, which uses a masked cysteine moiety, can be used to present a fluorophore or PEG particle bearing maleimide performance right into the product after the disulfide bridges have been developed. This technique has actually been applied to a variety of chemokine, enhance protein as well as conotoxin targets. Almac has considerable experience in the conjugation of peptides to a series of provider healthy proteins including keyhole limpet hemocyanin, Ovalbumin, Bovine Product Albumin, and also Human Lotion Albumin. Peptides are an expanding class of medicines, with buildings in between little particles as well as biologics. Insulin is a widely-used example of an establised peptide-based therapy.

With 50 years of experience as well as subsidiaries in Switzerland, the United States, the UK and Japan, Bachem is the companion of selection for the biotech and also pharma sector worldwide. Over 20+ studies have actually been released making use of the RALA system, varying from the basic style as well as application of an effective cell permeating peptide to use as a possible healing mRNA injection candidate. Variations around a hit particle can be made by utilizing various enzymes and also reaction plans, including more tailoring by oxidation of the heterocycles and also decor with prenyl teams.

The development of such a RNA replicase is commonly considered to mark the bottom line in the beginning of life. Research from Philipp Holliger's group in the LMB's PNAC Department has actually dropped new light on exactly how the RNA globe, and also its RNA replicase, might have first come to be dependent on short proteins, beginning the change to our modern biology. This latest paper discusses exactly how hydrolysed salmon peptides could change glycerine-- a nutritionally empty active ingredient-- in semi-moist pet snacks delivering high dietary protein value and also great palatability, along with other wellness benefits.

Ultimately, the authors of this publication hope to generate a spark of gratitude for the possible and also appeal of cyclic peptides, contrasting the rather slandering undertone reverberating along with their original word stem peptós. Head-to-tail-, side chain-to-side chain-, as well as side chain-to-terminus-cyclization.34,35 Several loops are also frequently discovered in peptides, e.g. a combination of a head-to-tail- as well as a side chain-to-side chain-macrocycle. Thus the most basic homodetic macrocyclic peptide is a covalent circuit built up of at the very least 4 deposits. However, smaller (non-macro-) cyclic concepts also occur having only a restricted number of constrained bonds. Figure 1.3 illustrates several of the most basic and also common motifs.34 Contrasting these structures, it promptly becomes clear that each specific setting of cyclization can result in a completely various geometry of the bent substance. Liquid-phase synthesis is a standard strategy for the synthesis of peptides.

N2 - We explain a method of isolating as well as assessing a solitary collagen peptide able to compare lamb as well as goat bone collagen. Microflow can assist in level of sensitivity gains for a wide array of analytes, yet the best advantage has been for peptides and healthy proteins. A DPhil pupil is called for to check out the technology further to seek opportunities to improve antigen discussion in both antigen presenting cells as well as target cells. This will be done via establishing one or two prospects of vaccines to preclinical phase. Bachem has confirmed efficacy of Trend Fluor fluorescent color in a a Förster Vibration Power Transfer evaluation of uptake of Amyloid β-Protein (1-42) by J774 macrophages, gotten from BALB/c computer mice. The Amyloid β-Protein (1-42) was labeled with Trend Fluor ™ 5WS fluorescent dye to enable visualization. The cells were presented in bright area imaging overlaid with the eco-friendly fluorescent network of the peptides.

Low bioavailability of the peptides is also a significant downside connected with peptide medications which is partly because of the inadequate membrane layer transportation ability of its amide backbone structure. • the first effective randomised professional tests in cancer clients that might lead to the very first FDA registration of a healing cancer cells vaccination within the following few years. pIII small coat healthy protein which shows a cell targeting ligand (e.g. RGD4C), which allows extremely targeted distribution to the target cell, for instance a tumour cell. Abdominal Muscle - We explain a technique of isolating and also evaluating a solitary collagen peptide able to distinguish between lamb and goat bone collagen. The 33 amino acid peptide from both sheep and also goat collagen was sequenced as well as shown to differ between both species at two settings. Evaluation of a variety of caprines showed that the series adjustments took place between the aberration of the Himalayan tahr as well as the ibex which the suggested goat marker is analysis of all Capra species and types.

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Cyclic Peptides In Biological

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Bioactive Healthy Protein And Also Peptides Market Players, Size, Cagr, Applications, Kinds, Analysis, Trends, Forecast To 2027.

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Unquenched Calibration Peptide For Snaptide ® 521. Vamptide ® Peptide Substrate (o.

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Common applications for these classified peptides consist of the Fluorescence (or Förster) Resonance Energy Transfer analysis of receptor-ligand interactions, protein-protein interactions and also the cleavage of substrate molecules. A novel antifungal bicyclic peptide from the aquatic sponge Theonella causes formation of vacuoles and overflow of 1, 3-beta-D-glucan. Theonellamide F hinders growth of different pathogenic fungi and also has cytotoxic properties versus L1210 and also P388 leukaemia cells. It can be used as important biomarker for the dimension of antigens and as a non-invasive technique for detecting invasive fungal infections. These can creating injury and also condition when in contact with body tissues, as they connect with biomolecules such as enzymes, hormones and also cellular receptors. Toxic substances vary significantly in their extent, varying from normally minor or intense reactions to fatality. There are you can find more information on workflow rules on direct peptides crm's help pages here. of ways to produce powerful bicyclic peptides, the most typical being phage-encoded libraries.

In specialist centers, utilizing B-type natriuretic peptide blood levels to overview treatment in individuals with chronic cardiac arrest shows pledge however did not enhance survival for all teams. In this evaluation, the advantage was just seen in individuals matured much less than 75, who endured an added 1.5 years usually, and possibly those with poor heart function.

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Utilizing this procedure a solitary direct peptide substrate will yield a distinct collection of modified cyclic peptides (5 in the instance received Fig. 2), each with a distinct conformation, and also a series of target binding as well as physicochemical properties. In all present-day organisms, info inscribed in DNA, the hereditary material of the cell, is transformed using an RNA intermediate into healthy proteins, the molecular machines of the cell. Nevertheless, proof recommends that in a far-off evolutionary previous our single-celled ancestors used only RNA for both hereditary information storage space as well as metabolic process. A cornerstone of this "RNA world" would have been an RNA able to reproduce itself.

Dispute Over Muscle-Building Drugs Goes to Court - Wall Street Journal

Dispute Over Muscle-Building Drugs Goes to Court.

Posted: Thu, 12 Oct 2017 07:00:00 GMT [source]

The Swiss based Bachem Group is a public, innovation-driven firm specializing in the growth and also production of pepTides and also oligonucleoTides. As a complete company Bachem offers items for scientific development and also business applications as well as a comprehensive directory and also exclusive personalized synthesis.

Bioactive Protein And Peptides Market Gamers, Dimension, Cagr, Applications, Types, Evaluation, Patterns, Forecast To 2027.

Now-a-days, it is getting changed with solid-phase synthesis due to its simplicity as compared to the previous. Nevertheless, liquid stage synthesis continues to be useful in the large production of peptides for commercial purposes. To try to find a peptide mimetic, it is very essential to determine a peptide or a peptide series within the target protein that is thought about for the assay. Structural constraints are taken into consideration to try to find the legitimacy of the functions.

Are SARMs a controlled substance?

This bill amends the Controlled Substances Act (CSA) to add SARMs (selective androgen receptor modulators) to schedule III. A SARM is a synthetic drug or substance that has effects similar to testosterone.

Bicycles can be readily recognized to medication a vast spectrum of targets as well as target classes, including several that have so far been undruggable with small molecules, such as protein-protein communications. This screening procedure self-selects for Bikes that are open to attachment-- commonly described as conjugation-- to other molecular payloads such as cytotoxins, inherent immune activators or various other Bicycles. Bikes can be connected together with artificial simplicity to produce complex molecules with combinatorial pharmacology. Additionally, Bikes in the form of multimers can likewise be used as standalone therapeutics, consisting of those that we are discovering in our T-cell modulator program. We believe that the versatility of our Bicycles as well as our powerful screening system allow new therapeutics to be quickly developed and decreased to exercise to possibly serve diverse healing applications throughout a wide variety of indications.

Cardarine Gw.

Bicyclic peptides such as the amatoxins as well as phalloidin include a connecting group, generally between two of the side chains. There are a number of cyclic peptide hormonal agents that are cyclised through a disulfide bond between 2 cysteines-- for instance, somatostatin and also oxytocin.

Does MK 677 increase testosterone?

MK-677 treatment reduced serum total testosterone (P

Rosario is an Elderly Scientist at the Medicinal Chemistry Institute (IQM-CSIC), Madrid. She is involved in peptides, second framework mimics and small-molecule peptidomimetics of application in biological/medicinal chemistry programs, specifically pertaining to the inflection of ion networks and connected proteins. The first medical trials of Modi-1, the lead candidate from the Moditiope ® platform, are anticipated to target clients with three-way unfavorable bust cancer, ovarian cancer cells and also osteosarcoma. To take advantage of the broad applicability of Bikes, we have entered into a number of collaborations beyond our inner emphasis in oncology. These tactical partnerships, each with partners that have deep restorative proficiency, are based upon the wide applicability of the exclusive Bike platform and its capability to address a wide variety of targets. These collaborations improve our capability to bring this crucial course of medications to patients with devastating diseases besides cancer cells.

Unquenched Calibration Peptide For Snaptide ® 521. Vamptide ® Peptide Substratum (o.

Phage strategies have actually been established for illness targets and also the generation of potent phage complied with by cyclisation of the phage-encoded linear peptides consisting of 3 cysteine deposits. The strategy was successfully applied on human plasma kallikrein inhibitors created with nanomolar fondness. Depsipeptides are peptides in which among the amide affiliations is replaced by a lactone affiliation. Some cyclic and bicyclic depsipeptides are cyclised between the C-terminal carboxyl and also the side chain of a threonine or serine deposit.

In researches of trained and also inexperienced computer mice, Cardarine triggered fast jerk muscle mass fiber to convert to reduce shiver muscle mass fibers.

Where Cardarine or GW50515 becomes very intriguing is that PPARD activation enhanced mitochondrial biogenesis in the muscular tissue, which can remodel your muscle tissue!

At just 1mg daily for 3 weeks a medical test showed an ordinary gain of 1.21 kg in LBM which is nearly 1 pound of LBM weekly which is absolutely insane thinking about the moment frame and also the reality that they were not even training.

Unlike Ostarine, LGD-4033 does not seem to boost liver enzymes nonetheless like Ostarine it did adversely influence great cholesterol degrees.

As a result of this Cardarine is usually called an exercise mimetic as just workout could typically make these adjustments to your metabolism and also fiber composition.

The typical results from this are 7-10lbs of LBM, great rises in strength and little to lean loss.

The common dosage for efficiency improvement is 2-10mg each day for 4-8 weeks.

The survival of these pens in archaeological bones was tested utilizing a collection of 26 ovicaprid specimens from Domuztepe, a Neolithic website in south main Turkey. These markers were used to examine the osteological decision of 24 of the Domuztepe bones, and also figure out the types for 2 immature specimens. The collagen-peptide approach has benefits over various other non-morphological approaches of sheep/goat distinction as a result of the long-term survival of collagen over other biomolecules such as ancient DNA. The results likewise highlighted the issues in trusting one morphological standard, in this case on the distal radius, to compare sheep and also goat bones.

The Real Deal For Sarms In The Uk.

Our screening system can be released to evaluate either soluble proteins or cell-based targets. In addition to being resource-efficient as well as quick, the procedure distinctly utilizes an integral on-phage binding assay that notifies structure activity relationships. We can integrate a wide series of tiny molecule scaffolds into Bicycles to increase diversity and provide differentiated physicochemical and architectural residential or commercial properties. , Techniques to improve plasma fifty percent life time of peptide and also healthy protein medicines, Amino Acids, 2006, 30, 351-- 367 CrossRef CAS PubMed. , Evaluation cyclic peptides on a merry-go-round; in the direction of medicine layout, Biopolymers, 2015, 104, 453-- 461 CrossRef CAS PubMed. , Impact of bulky side chains of amino acids on the solution conformation of peptide fragment (81-92) by-products of CD4, TYICEVEDQKEE, as studied by NMR spectroscopy as well as molecular modeling, Biochim. , Constricting cyclic peptides to mimic healthy protein framework concepts, Angew.

However, there was a reduction in healthcare facility admissions for heart failure for every person. Toni Weinschenk got his PhD in Immunology at the University of Tuebingen. He has actually created the innovation platform XPRESIDENT, which incorporates methods from peptidomics, genomics and immunology in order to locate unique and normally presented cancer cells antigens. The platform is commercialised by immatics biotechnologies, where Toni Weinschenk, likewise a co-founder of the business, is heading the medicine exploration team. Utilizing a hydrolysed healthy protein can help to lower GI and/or dermatological indications as the hydrolysed protein is not able to crosslink receptors on pole cells, consequently reducing degranulation and also release of histamine. Bradykinin is an inflammatory arbitrator as well as a vital regulatory authority of high blood pressure, kidney feature and also heart function, and additionally associated with swelling.

By customizing the amino acid series we can manage whether these peptides construct right into hydrogels made up of nanofibers or peptide nanotube frameworks. We have actually created our very own internal modern technology to allow for the post-folding labelling of tiny healthy proteins. This method, which uses a concealed cysteine moiety, can be utilized to present a fluorophore or PEG molecule birthing maleimide performance into the item after the disulfide bridges have been created. This approach has been put on a number of chemokine, enhance healthy protein and conotoxin targets. Almac has substantial experience in the conjugation of peptides to a variety of provider healthy proteins consisting of keyhole limpet hemocyanin, Ovalbumin, Bovine Lotion Albumin, and Human Product Albumin. Peptides are an expanding course of drugs, with buildings in between tiny particles and biologics. Insulin is a widely-used instance of an establised peptide-based therapy.

With half a century of experience and also subsidiaries in Switzerland, the USA, the UK and also Japan, Bachem is the partner of selection for the biotech and pharma sector worldwide. Over 20+ research studies have been published making use of the RALA system, varying from the fundamental design and also application of an efficient cell passing through peptide to make use of as a potential healing mRNA vaccination prospect. Variants around a hit molecule can be made by utilizing various enzymes as well as response schemes, consisting of further tailoring by oxidation of the heterocycles as well as decoration with prenyl groups.

The introduction of such a RNA replicase is extensively considered to mark the key point in the beginning of life. Study from Philipp Holliger's group in the LMB's PNAC Department has dropped new light on just how the RNA globe, and also its RNA replicase, may have very first come to be dependent on short proteins, starting the transition to our contemporary biology. This most current paper goes over how hydrolysed salmon peptides might change glycerine-- a nutritionally empty component-- in semi-moist animal treats delivering high dietary protein value as well as great palatability, together with other health and wellness advantages.

Lastly, the writers of this book want to generate a trigger of admiration for the possible and also elegance of cyclic peptides, contrasting the rather disparaging touch reverberating along with their initial word stem peptós. Head-to-tail-, side chain-to-side chain-, and side chain-to-terminus-cyclization.34,35 Numerous loops are also on a regular basis found in peptides, e.g. a combination of a head-to-tail- and also a side chain-to-side chain-macrocycle. Thus the simplest homodetic macrocyclic peptide is a covalent circuit developed of at least 4 residues. Nonetheless, smaller sized (non-macro-) cyclic themes likewise take place including just a restricted variety of constricted bonds. Number 1.3 shows a few of one of the most basic and typical themes.34 Comparing these frameworks, it immediately becomes clear that each specific mode of cyclization can lead to a completely different geometry of the looped compound. Liquid-phase synthesis is a traditional strategy for the synthesis of peptides.

N2 - We define a method of separating and assessing a single collagen peptide able to compare lamb as well as goat bone collagen. Microflow can assist in https://poland.direct-peptides.com/ for a variety of analytes, yet the greatest benefit has been for peptides as well as healthy proteins. A DPhil student is required to discover the modern technology further to look for opportunities to improve antigen discussion in both antigen presenting cells and also target cells. This will be done through developing a couple of candidates of injections to preclinical phase. Bachem has actually confirmed effectiveness of Tide Fluor fluorescent color in a a Förster Vibration Power Transfer analysis of uptake of Amyloid β-Protein (1-42) by J774 macrophages, gotten from BALB/c computer mice. The Amyloid β-Protein (1-42) was classified with Trend Fluor ™ 5WS fluorescent dye to make it possible for visualization. The cells were displayed in intense area imaging overlaid with the eco-friendly fluorescent network of the peptides.

Reduced bioavailability of the peptides is additionally a major disadvantage associated with peptide medicines which is partially due to the inadequate membrane layer transportation capability of its amide foundation framework. • the very first successful randomised professional trials in cancer people that might result in the initial FDA enrollment of a healing cancer cells injection within the next few years. pIII small coat healthy protein which shows a cell targeting ligand (e.g. RGD4C), which allows extremely targeted delivery to the target cell, for instance a tumour cell. ABDOMINAL - We describe a technique of isolating and also evaluating a single collagen peptide able to distinguish between lamb as well as goat bone collagen. The 33 amino acid peptide from both sheep as well as goat collagen was sequenced as well as revealed to vary in between both varieties at 2 placements. Evaluation of a variety of caprines indicated that the series modifications occurred between the divergence of the Himalayan tahr and also the ibex and that the recommended goat marker is analysis of all Capra varieties and breeds.

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The encoder can be either incremental or absolute. Motion can be determined by change in position over time. Linear encoder technologies include optical, magnetic, inductive, capacitive and eddy current. Optical technologies include shadow, self-imaging and interferometric. Linear Encoders are used in metrology instruments, motion systems and high precision machining tools ranging from digital calipers and coordinate measuring machines to stages, CNC Mills, manufacturing gantry tables and semiconductor steppers. Scope of the Report: This report focuses on the Linear Encoders in Europe market, especially in Germany, UK, France, Russia, and Italy. This report categorizes the market based on manufacturers, countries, type and application. Market Segment by Manufacturers, this report covers NEWALL RSF Elektronik Lika Electronic GURLEY Precision Instruments Electronica Mechatronic Systems Kubler Fagor Automation SIKO GIVI MISURE Leader Precision Instrument Market Segment by Countries, covering Germany UK France Russia Italy Market Segment by Type, covers Incremental Linear Encoders Absolute Linear Encoders Market Segment by Applications, can be divided into Machine Tools Measuring Instruments Motion Systems Elevator Others There are 17 Chapters to deeply display the Europe Linear Encoders market. Chapter 1, to describe Linear Encoders Introduction, product type and application, market overview, market analysis by countries, market opportunities, market risk, market driving force; Chapter 2, to analyze the manufacturers of Linear Encoders, with profile, main business, news, sales, price, revenue and market share in 2016 and 2017; Chapter 3, to display the competitive situation among the top manufacturers in Europe, with sales, revenue and market share in 2016 and 2017; Chapter 4, to show the Europe market by countries, covering Germany, UK, France, Italy and Russia, with sales, price, revenue and market share of Linear Encoders, for each country, from 2012 to 2017; Chapter 5 and 6, to show the market by type and application, with sales, price, revenue, market share and growth rate by type and application, from 2012 to 2017; Chapter 7, 8, 9, 10 and 11, to analyze the key countries by manufacturers, Type and Application, covering Germany, UK, France, Italy and Russia, with sales, revenue and market share by manufacturers, types and applications; Chapter 12, Linear Encoders market forecast, by countries, type and application, with sales, price, revenue and growth rate forecast, from 2017 to 2022; Chapter 13, to analyze the manufacturing cost, key raw materials and manufacturing process etc. Chapter 14, to analyze the industrial chain, sourcing strategy and downstream end users (buyers); Chapter 15, to describe Linear Encoders sales channel, distributors, traders, dealers etc. Chapter 16 and 17, to describe Linear Encoders Research Findings and Conclusion, Appendix, methodology and data source

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CURRENT COSMIC ENERGY UPDATE: Mass Exodus & Changing Dimensions 3/11/2019 Tuning into the Cosmic Energies and Varying Collectives occurring, as a part of the Grand/Great Awakening Processes, in varying stages, phases and vibrational frequencies (bandwidths), with each bandwidth "playing out" their relative roles..... As each collective awakens, through the activation of Photonic Light, which occurs on a cellular level within each's body (LightBody), each dimensional body (carbon based, crystalline, plasma), experiences "REAL"ity very differently..... I started a sharing/writing last year that I never completed (it had to take a back seat to our other service roles here), which broke down each dimensions LightBody, starting with the 3rd. Until each becomes fully aware of how all works (from inside), then everything is speculation/supposition and so not understood.... because of how each "measures" and "sees" is still through fractals/old parameters of "what reality is".... For this sharing/article, I will break it down a different way and at some point, complete that article/writing and release it/provide it for those it may assist.... Right now, we have a MASS EXITING occurring... from the "Group Think Mind" of "mind control". Now, I do not use these words to support "I'm a victim", yet the opposite... of the POWER THAT EACH TRULY HOLDS when their own deep inner sacred connection is the POWERFUL FORCE within their own reality and each functions from this place/space inside. Re-establishing our own deep inner-connection with PURE SOURCE CONSCIOUSNESS, will take on many "forms" along the way. As each moves through each Lightbody DNA upgrade/phase, more awareness, more information, more understanding of HOW ALL COMES TO BE CREATED becomes visible... yet at first, without this VISIBILITY (ability to see multi-dimensionally), the version of the "truth" is still a bit "slanted", based upon "individual stories" vs. the much bigger picture that doesn't involve "I was a victim" anymore.... As each AWAKENS to their own SUPREME POWER inside... to the awareness, realization and understanding that they were deep asleep and living deeply embedded in realities that were blanketed in "untruths", held together by "fears", an illusion we all "bought", because it's a part of the "being deep asleep process", which is also a part of "breaking out of that prison/programs/conditioned beliefs (hell)" and deciding to shift perceptions, shift beliefs, shift "alliances" and eventually "shift versions of Earth's we live on".... (from Old Earth to NEW). Many are unaware there's totally different Versions of Earths all running simultaneously, at the same time and for each to "shift" over to a different/alternate/higher consciousness version, each must open their hearts to allow PURITY LOVE CONSCIOUSNESS to EMERGE from within.... and "how each gets here" is not what anyone "thinks" or is "typical". This is the most "untypical, un-orthadox, un-conforming, illogical process" (to the human aspect), because HOW isn't a linear process and the "ways" are not typical or "normal" or available in "one video or book"..... At first, "leaving" or "going against" everything one has been told, conditioned to believe and "thought", it's scary as hell... (which is the point), as the conditioning was meant to "keep" everyone in a reality SO SCARED to GO AGAINST... that the programming becomes the belief which then dictates the physical reality.... of how all "lived". Because each's WHOLE LIFE was built upon a facade.... built upon fears and beliefs so drilled in, so deeply embedded, so "marketed" as true, with books, education and entire societies/communities/cities constructed to uphold this "illusion", to make "unconsciousness" easy... when it's time to emerge from the illusion, from the deep state/sleep/slumber/amnesia of what IS REALLY REAL... CONFUSION, fear, anger and blame are the "first parts of this awakening" process... because each "feels duped", yet this is a part of the illusion too. RIGHT NOW, we are in Mass Exiting (once again), as the "next collective" (a much larger one) emerges from the illusions, emerges from the deeeeeeeeep deeeeeeeeep sleep, where illusions and distortions ruled.... and due to "acceptance", were allowed to have control, because FEAR is the ENERGY THAT HELD ALL THERE.... yet.... These COSMIC RAYS AND CONTINUALLY ACCELERATING SOLAR (SOULar) Activity, the increase in ULTRA HIGH FREQUENCIES do many things, all important in this mass awakening/ascension process for all on "this planet" (and beyond). These ultra-high photonic, sonic, gamma, (and so much more) frequencies GO STRAIGHT to the cellular body/DNA, straight to the program, go straight to the constructs, straight to the SOURCE of where all was "housed" (within the body), to activate, stimulate and create a disruption in the old frequencies that kept each "bound" to that dimension/density/reality.... These Cosmic/SOULar Frequencies are LIGHT ENCODEMENTS that disrupt the old "signals" that held the old illusions in place. They go straight to where EACH'S DNA is "waiting" to be activated to AWAKEN FULLY, yet the human aspect is unaware of all still, because there are so many programs, mentalities, beliefs, illusions, distortions to clear in order for one's PHYSICAL BODY/LIGHTBODY to awaken enough through CONSCIOUSNESS to clear the heavy-duty density held within.... This is as much a physical process as it is an energetic one. This is an immense emotional process for awhile, clearing all the hurt, betrayal, inner-pain, anger, hate and distrust, blame, shame, guilt and so much more.... and the process "takes as long as it needs to take", which is often years, because not only must the emotions clear/cleanse the body, the thoughts, the physical density, the beliefs, the resistance and the HOLD THAT EACH'S EGO HAS... every bit has to be "reworked" vibrationally, literally.... in every way. All while the physical reality is being aligned too. Every compromise, every acceptance of anything not PURE, every suppression, every avoidance, every linear thing created/held, every attachment, every lack (power, love, inner-connection), must not only BE REVERSED... all new everything must be created to replace the old.... NEW UNDERSTANDINGS, new access, new ways... of doing things, of thinking, of acting, of living.... our entire lives have to be re-built, re-aligned and re-configured to align on a Universal/Soul/Cosmic Level... which is not an easy task, because "outside" isn't where we go to get our answers (except at first, when we seek/utilize guides to point us inwards to find our own truths/answers, which is the opposite of giving our power away to anyone else)..... Part of the process, for awhile, when collectives are EXITING the old ways, when one has not fully come into their own deep-sacred connection/power within, they will seek outside for "others" to tell them what to do.... because the old way was "rely on others, rely on someone else to think for me", because each doesn't yet "know how" to "think" for themselves... this will create another distortion/parallel experience, if you will, if there are any impurities within the seeker, any compromise of soul/self, any "hand my power over to others", then the cycle of "repeating" an experience to learn WHAT NOT TO DO/BE will occur, as it's a part of each's "learning process" here. There's often alot of drama when this happens, because of the depth of the emotions each still holds and the depth of DEPENDENCY ON OUTSIDE vs. SOVEREIGNTY, which is a part of the transition out of 3D/4D into 5D/NEW Earth Realities.... Let's talk about NEW EARTH for a moment... because I see so many that still don't understand. NEW EARTH IS A VIBRATIONAL REALITY that operates at the FREQUENCY OF SOUL LOVE, where each awakens to beauty, magic, magnificence and a profound sense of PEACE, HOME, bliss, magic and all of this JOY and AMAZINGNESS that we all disconnected from/forgot/were disconnected from, while living beneath the veils (within). As we sleep, as we rest, as we reconnect with nature, as we all go through our own "Dark Nights" (Ego Dissolution/Death), what AWAKENS/EMERGES within US is OUR OWN LIGHT.... is our CONNECTION WITH/AS PURE SOURCE CONSCIOUSNESS, where OUR WHOLE LIFE CHANGES, because we've REMEMBERED the ABUNDANCE, we've REMEMBERED the FREEDOM, we've REMEMBERED THE PURITY and the brilliance and our own INNOCENCE, without the distortions/separation/programs... and then it's a process of re-structuring, re-building, creating, re-aligning EVERYTHING WITHIN US and OUT THERE with these "new understandings" (realizations/awarenesses) that DON'T CONFORM TO THE OLD..... This is a process, years and years and years of linear "time", yet because we don't "live" from the linearity anymore, because we function from ZERO POINT, PURE PRESENCE, every dimension/reality/possibility opens up.... through our LIGHTBODIES and our SOURCE CONSCIOUSNESS DNA activating 24/7, as linear goes out the window, our bodies have to continually go through an immense re-writing process through the INTEGRATION OF LIGHT(CODES) that re-do everything FOR US.... and because we function from an "EGO SURRENDERED STATE" our ACTions are PURE... which can be "read" energetically by all tuning into this... OUR LOVE, on a SOUL LEVEL, on a Cosmic Level, on a Galactic Level, every level... can be felt.... this is our ENERGY SIGNATURE that CONNECTS US ALL as PURE SOURCE LOVE CONSCIOUSNESS here.... For each one of us to come to LIVE FROM THIS PLACE/SPACE fully, we all had to be "faced" with everything "not pure". It's a part of the process of CHOOSING and re-aligning all of our realities, which is what collapses/dissolves the old unconscious dimensions, as they were all held in place by each one of us, because we believed "that", because we conformed, because we allowed, because we became submissive... without any awareness that we were... AWAKENING CHANGES ALL --- First, there's each's AWAKENING, THEN ASCENSION BEGINS... this is a totally different PART/PHASE of the whole process... where each RETURNS to a Christed/Pure State of Consciousness, through DIVINE SOUL UNION WITHIN.... this is where everything starts to become VISIBLE ON A WHOLE NEW LEVEL, one that's not personal in any way, one where there are no victims or perpetrators, because "access" starts to return.... NEW EARTH IS ASCENDED EARTH...which means each LIVES AS THEIR ASCENDED ASPECTS, as pure love, as Conscious Light BEings, yet there are varying levels of this too, as this accelerates all new phases relative to various LightBody phases, as each EMBODY'S FULLY and re-aligns their whole life too..... This is not an "easy" process of re-constructing our entire reality according to all new "codes", because the more unconscious and deeply embedded/asleep we were, the more we go through to awaken and 're-do". NEW EARTH IS EXPERIENCED FROM DEEP INSIDE. IT'S OUR PURE LOVE and OUR DEEP SACRED CONNECTION, IT'S A FULLY REMEMBERED STATE where our bodies and physical realities are constantly shifting into much higher states of consciousness than before, yet the oscillation rate of these cycles INCREASE to be so "fast", that all linearity goes and we live from a fully Quantum State of Consciousness that doesn't' function like linear/dense realities did. We all gain the abilities to TUNE OUR CONSCIOUSNESS to varying levels and frequency bandwidths, which open up portals, gateways, passageways to varying dimensional realities that already exist (because all has already occurred) and we function from 'THOSE', while we "do" our every day, which is very different than the old ways, in every way. How we move through all, how we see, how we do all... becomes very simple, because the density (slowness which is relative to processing speeds/light) is very different too.... NEW EARTH IS WHERE WE LIVE INSIDE, as Photonic Light BEings, as Soul-Star-Light BEings, with photonic/plasma access and realities that are fluid, synchronized with a Cosmic Rhythm and Harmony that's always "in-tune". When it's not, we know it and we honor this, yet our capabilities are different, because of the PEACE, LOVE, HARMONY WE HOLD WITHIN.... We treat everyone with immense kindness, we truly care, we are able to maintain our own Deep Sacred Connection with all, so we never shift out of pure gratitude, appreciation and living from an abundant state, which means that we don't hold the conditioning, programming and limits of the old. We share, we support, we inspire, we uplift, we live from PURE JOY and recognize all... We see everything, without the blinders/cords/illusions of before. We see PURITY and we SEE lack.... which gives us the ability to assist/guide others who are open to accessing/achieving this within themselves fully too, yet we have no desire to take on the responsibility of others energetically saying they are not ready to do what it takes to live PURITY CONSCIOUSNESS from within themselves yet. We understand what compromise creates, we understand how we each have to choose, because in the choosing, we take responsibility and are saying WE ARE READY TOO. The responsibility we speak of is not like the old ways.... it's a very different responsibility (many argue this, yet that's ego matrixes too). Our RESPONSIBILITY is to HOLD THE HIGHEST STATES OF CONSCIOUSNESS AS LOVE HERE and to SHOW THE WAY, LIGHT THE PATH and BE THE ONES/THE CHANGE and to create the space and hold it for all others to choose this fully too. NEW EARTH IS AN ENTIRELY NEW MATRIX SYSTEM, YET IT'S NOTHING LIKE THE OLD It's a Crystalline/Christed "matrix" that is connected and woven through LIGHT. It's a NEW SYSTEM that we all CREATE AND LIVE as Ascended (Returned/Remembered) Light BEings here. It's us inner-connected, us as ONE, it's WE CONSCIOUSNESS through UNITY and PURITY and UNITING to BE NEW EARTHERS here. WE Shine Light, WE Share as Light, WE affect all as LOVE and we hold the "new" in place... as the "new" is not "new"... it's what we all "lost"/disconnected from/forgot, while living beneath the veils.... THE VEILS ARE INSIDE, IT'S THE SEPARATION ALL HOLDS, IT'S PHYSICAL MATTER/DENSITY as well as immense unconscious programming represented by suppressed/repressed emotions/thoughts, beliefs/mentalities of less, lack, fear, judgement and the ABSENCE of PURE DIVINE LOVE. NEW EARTH .... you/we BECOME and ARE NEW EARTH... WE, as multi-dimensionals can see/experience all from a multi-dimensional level and choose from a multi-dimensional level too. One cannot just "say the words" that sound intelligent or pretty or cool... HERE ALL HAVE TO LIVE IT, BE IT and our ENERGY SPEAKS FOR US.... as all is VISIBLE HERE.... because we live as ENERGETIC BEINGS, WE READ ENERGY, WE COMMUNICATE ENERGETICALLY and words are only use to describe, teach, explain and bring into a higher state of consciousness, what "isn't yet". In the beginning, NEW Earth isn't even real. Then it becomes a place we see in our sleep or waking state DREAMS.... then we start to experience it through subtle inner-actions that are silent, connected and peaceful, pure and innocent... yet then the process begins of "HOW TO LIVE THIS ALL OF THE TIME", which is where all of our parts come in.... We sleep/dream ourselves awake and anchor dreams from our "dream state" into/through our physical here. THESE COSMIC FREQUENCIES and PHOTONIC LIGHT assist with transitioning from parallel to parallel to alternate realities and clearing distorted ones.... these photonic frequencies do everything only understood as/after we go through it all... as the KNOWLEDGE FOR HOW comes through our own actual experiences here, otherwise it's just regurgitation, just like old earth realities were.... A fully SOUL ALIGNED REALITY is SIMPLE and not creating fractals/parallels to experience (learn from) anymore. As each come to TRULY UNDERSTAND that there's not just ONE VERSION OF EARTH RUNNING ANYMORE..... it makes it easier for each to "choose" a much higher dimensional version than before. As each truly come to understand (get it deep within), that NEW EARTH IS OUR PHYSICAL REALITY EXPERIENCES that are a VIBRATIONAL MATCH TO US... (as is old earth, yet focusing on NEW EARTH right now)..... EACH STARTS TO PAY ATTENTION to what they are holding, transmitting, allowing, believing, calling forth and surrendering to, understanding that it's OUR OWN ENERGY and HOW WE SHOW UP/ACT that determines the experiences we all have here. We've reached another nexus point, a turning point if you will, another one, because these are always occurring as we all continually up-shift, while anchoring/integrating/holding higher states of consciousness from within us and radiating this out to affect, shift, recode all..... When I awoke to the words "Mass Exodus", I had to go look up Exodus to see what it meant. If everyone drops the "linear" and looks at the energy/metaphor... it relates to masses exiting the "slavery of humanity" phase, which correlates to the "survival mode" where enough hearts have opened fully for more to transition through higher awareness, instead of living by the old conditioning held in place by "fear". Yes, clearing fear, judgement, lack is an immense process, because it means going deep within. We are going to see the most intense DARK NIGHT for many collectives going through their own "exit"/transition processes of resolving separation/duality within, so that their own LIGHT CAN BURST THROUGH and be their own Guiding Light too... The process of RE-CONNECTION and REMEMBERING and ONENESS occurs within each one of us as we are ready and our hearts open enough, as our walls of Armour/protection come down, as our own distortions come up for us to see/clear and as WE DO THIS OURSELVES... We can be guided, we can be assisted... along the way, yet no one can do these parts for us, we have to do them ourselves... and the human ego aspect has been convinced/convinced itself it's not able/capable/can't and "needs" something/someone else to "help". Yes, we have to open up to this, if we were so strong we wouldn't allow ourselves to be vulnerable, open and "seen", yet there's a huge difference in opening to that softness and relying on others, which is just "displacing our own POWER" again.... NEW EARTH.... all are Sovereign and not playing out lack games, not blaming others, not taking on others stuff and clearing the immense DISTORTIONS OF LOVE. OUR LOVE IS PURE.... and through this purity we will hold all to a place of Sovereignty, because we don't see the lack. We see the stories, the BS, the games that the ego plays, yet we see the beauty, the purity and the magnificence of EACH when all are LIVING AS PURE SOURCE CONSCIOUSNESS LIGHT too... A NEW EARTH EXISTENCE means that you live free from the old distortions, free from the lack, free from the programming/CONDITIONING and you live from your Quantum State too.... It means that you show up, you hold your own, you are kind and you "get it all" with your whole being and you don't bring your lack to the table, because that's all the old BS programming and illusion that we all see beyond. NEW EARTH is YOU LIVING AS A NEW EARTHER... you living as LOVE... you fulfilling your highest roles/purposes/missing, without "needing" anything... because you've cleared your own akash, because you've REMEMBERED and you are excited to share, excited to uplift, excited for all to UNITE, to create, to strengthen the NETWORK of all of us who are RECONNECTED on an ENERGETIC LEVEL with Gaia, Universally, Cosmically.... NEW EARTH IS YOUR "CREATION", it's you LIVING YOUR MAGIC AND JOY... and it's you being visible, open, honest, REAL and not making an apology for not conforming to the old lack systems of old earth anymore.... because you've TRANSCENDED THE BELIEFS, the programming, the mentalities and the ENERGY of SEPARATION from deep within you too... you are not projecting your "stuff" and you are not taking on "others" "stuff".... that was the old ways too... IT'S ALSO you/all of us fulling higher service roles. NEW EARTH is you respecting all... from the DEEPEST MOST SACRED AND CONNECTED PLACE WITHIN YOU... living from this DEEP SACRED RESPECT with your every act, with your every breath and not accepting any less ever again.... because you don't have to, because you woke up and YOU'VE REMEMBERED YOURSELF AS PURE SOURCE CONSCIOUSNESS too. Drop the ego games, drop the "fronting", drop the "pretending", drop the "stories", drop it all.... as THAT is your DIS-EMPOWERED and DIS-CONNECTED STATE of Consciousness.... IF YOU TRULY OPEN YOUR HEART AND MIND AND WHOLE BEING and UNIFY TO/FROM/AT your absolute highest FREQUENCY OF PURE LOVE and you walk as this throughout your day, you live as this with your every ACTion, you breathe this as your ONLY REALITY then it's guaranteed that your "REAL"ity will "change". This is because YOU ARE BEING LOVE and you are treating others with kindness, consideration, respect, compassion and taking all into CONSIDERATION - BEFORE you allow your old programming to enter back in. WHEN YOU HOLD THIS EXPANDED STATE ABOVE ALL AND YOU LIVE IT FULLY.... NEW EARTH WILL BECOME YOUR ONLY REALITY TOO. Location will not matter, the people won't matter... because the LIGHT YOU HOLD DICTATES....and once you are able to hold this fully "no matter what", then your physical will start to take new shape, open up new opportunities, open up new possibilities and "take you in new directions", because you changed your whole vibration to a whole new dimension, so the next steps are to move your body to the new physical dimension or to experience the new physical dimension as it arrives for you! ♥ As you LIVE FROM NEW EARTH INSIDE OF YOU.... NEW EARTH WILL "APPEAR" (MATERIALIZE) OUTSIDE as a vibrational/energetic response to you.... This is how we all do/did it. This is how we "know". ♫ Happy magical everything. "How long is up to you". "When" is too... as time is not linear, it's vibrational and relative to the amount of LIGHT HELD... as we go "up" in vibration and "expand" out.... to experience the vastness of multiple dimensions all simultaneously, which is how MULTI-DIMENSIONAL EARTH IS EXPERIENCED for all of us here. ♦ NEW EARTH IS WHERE WE ARE RE-BIRTHED THROUGH/TO EXPERIENCE/LIVE... HEAVEN ON EARTH BECOMES OUR NEW HOME (INSIDE AND OUT), BECAUSE WE LIVE FROM HEAVEN WITHIN... WE DON'T CHOOSE/ALLOW HELL ANYMORE. THAT WAS A PART OF THE OLD ILLUSORY PROGRAMS HELD WITHIN US ALL TOO. Lisa Transcendence Brown ☼ www.AwakeningToRemembering.com

[designfordisplay]

Marstine, J. (Ed) (2006). New museum theory and practice: An introduction. Malden, MA: Blackwell.

Notes:

Museums are so ubiquitous/omnipresent in our  ‘“cultural landscape that they frame our most basic assumptions about the past and about ourselves”.

A lot of people’s perceptions of history are based of what is displayed in museums. This can be dangerous as it can manipulate and focus people’s mindsets, not allowing for alternate and contradicting histories - Hiroshima vs Enola Gay.

Huge controversy over who the items may belong to - a lot of Maori taonga was confiscated and taken and is not connected to its whakapapa. These such items on display have tikanga surrounding how it should be handled etc.. te papa enforced the mana taonga principle to ensure cultural significance and history are taken into consideration when dealing with taonga. Tribal elders are also asked for advice. Other places do not have respect for the items in their possession or do not care that they are reunited with their whakapapa - what ever culture they may be from. Such as the elgin marbles of greece who are in in the possession of the British Museum where they refuse to return them - stating that they were “rescued” and that the british are keeping them still to guard against damage from the neglect, earthquakes and pollution they might face in greece. Timothy webb says that they have come to represent britain as the “inheritor of democracy from ancient athens” and in turn, justifying their “political” decisions such as “colonisation and domination of other peoples”. Greece is seeing this as a humans rights issue- sculptures were gained through illicit means (stolen) and they are being denied of their heritage.

We see museum objects as ‘unmediated anchors to the past’ - teachers often take students to museums making real of the things talked about in class.

But they’re not authentic a lot of the time, museums are about individuals making subjective choices - mission statements, architecture, exhibition display etc.. what is meant to be a neutral space is influenced by ‘subconscious’ opinions.

What does it mean for something to be ‘authentic’? “Claiming authenticity is a way for museums to deny the imperialist and patriarchal structures that have informed their institutions. They control the viewing process and suggest a tightly woven narrative of progress, an ‘authentic’ mirror of history.

Andreas Huyssen believes that museums are a mass medium, “a hybrid space somewhere between public fair and department store”. ‘They are a response to the quest for authenticity fueled by the cultural amnesia of our times; the information overload and fast pace of the digital revolution evoke a desire for stability and timelessness.

Museums are well trusted, american association of museums survey, 87% deem museums trustworthy vs 67% books and %50 tv news.

New museum theory (critical museum theory/new museology) - while workers ‘naturalise’ their policies and procedures as professional practice, the decisions made reflect underlying value systems that are encoded in institutional narratives. Its about decolonising and giving those represented control of their own cultural heritage (mana taonga principle) real cross-cultural exchange. 1960s artists began to demand a voice in determining how their works were displayed, interpreted and conserved. The civil rights movement challenged the museum to be more inclusive.

What is a museum? These categories are not mutually exclusive and overlap.

Shrine: longest standing and most traditional view of the museum is as a sacred place. Has therapeutic properties, place of sanctuary removed from the outside world.collections are fetishised, objects ‘possess’ an aura that offers spiritual enlightenment. Leads people to assign meanings to objects unrelated to their original function. Objects are prioritised over ideas. Collections are thought to be reborn in museums, where they are better guarded and more appreciated. The shrine idea is influence by church, palace and ancient temple architecture - processional pathways, staircases, dramatic lighting.. Create and performative experience. ‘All museums stage their collected and preserved relics… (museums) use theatrical effects to enhance a belief in the historicity of the objects they collect.’ - Prezoisi.

market-driven industry: museums often position themselves as being ‘pure’ and unsullied by commercialisation. Obviously people understand the items are valuable but this information is usually hush hush - would commoditise the objects. Heritage and tourism are collaborative tourism. Museums have borrowed from the theme park and cinema to create a spectacle that engages all the senses.

colonising space: often look to/reference a postcolonial (eurocentric perspective) history. Appropriate objects from non-western cultures to tell their own history. Naturalise the category of ‘primitive’. Indigenous individuals were rarely acknowledged - seen as following conventions while ‘original’ western artists were seen as groundbreaking and intellectuals. Destroys rather than preserves. UNESCO declared that repatriation is a basic human right. Mansuline gaze

Post-museum: no longer a museum. Will acknowledge the politics of representation, actively seeks to share power with the communities it serves and the source communities. Encourages diverse groups to respond in museum discourse. Curator takes responsibility for representation. Doesn’t shy away from difficult issues but exposes conflict and contradictions. Redress social inequalities. Promote social understanding. Responsibility always rests with the researcher

Greater accountability, sensitivity and openness

Michel foulcault - epistemes -

Renaissance:15/16/17th century humanist desire to understand the world through seeking universal knowledge.science over theology. Finding relationships between objects, microcosm of god. Curiosity cabinet - mediates between the microcosm of humankind and the macrocosm of god and the universe. Precursor of the museum to represent the world in miniature - was private though

Classical: mid 18th century world was too complex, chaotic and fragmented to be contained in the cabinets. Linnean taxonomy classifies the natural world by genus and species. Repositories, study collections that were privated were founded for scholarly research. The rare in the laws of nature was rejected and seen as uncharacteristic or were made to fit in. displays were linear and embrace an ideology of progress.

modern: late 18th century marks the end of elitist institution and beginning of democracy. Military practice became standard. Biology and philosophy arose. Disciplinary public museum  -accessible to all. Aimed to fashion modern citizens. Art was royal, aristocratic or ecclesiastical contexts and reclaimed national patrimony and democratise and secularise the viewer. Temporary exhibitions were formed to celebrate napoleon's birthday.

(can’t change) Many believe museums still conform to this modern model. They may create new spaces and exhibitions for consumptions but at heart, remain elitist institutions. The decision making process often refrains from scrutinising their own histories. Continue to attract (more art galleries) an educated upper and middle class audience, often times remaining irrelevant to marginalised groups. They aim to generate consensus rather than conveying differing perspectives. Curators are above education department. Quantitative vs qualitative.

Are museums able to change or are they becoming obsolete?

(can change) they can because deconstructing the traditional value systems in just the beginning. Can occupy a third space, beyond elitism and consumerism. Some curators are eager to share power by initiating open dialogue and forging new partnerships with groups previously disenfranchised. There are many organisations that are taking diverse approaches to the representation of race, ethnicity, class and gender. Time of the museum as a ‘great collector’ is past. Provenance is important to consider!! Finding culturally sensitive ways to treat non-western objects. Museum is more than a material collection - a lot are still stuck with this. FORUM.

Biggest change comes with the relationship between institution and audience - should be equal. Some are supporting educational research that theorised the museum experience. Acknowledging diverse learning, lectures, performances, videos, workshops etc…

Constitionaries

Visitors must be critical about the choices made by museums.

[srasamua]

Using Python to recover SEO site traffic (Part three)

When you incorporate machine learning techniques to speed up SEO recovery, the results can be amazing.

This is the third and last installment from our series on using Python to speed SEO traffic recovery. In part one, I explained how our unique approach, that we call “winners vs losers” helps us quickly narrow down the pages losing traffic to find the main reason for the drop. In part two, we improved on our initial approach to manually group pages using regular expressions, which is very useful when you have sites with thousands or millions of pages, which is typically the case with ecommerce sites. In part three, we will learn something really exciting. We will learn to automatically group pages using machine learning.

As mentioned before, you can find the code used in part one, two and three in this Google Colab notebook.

Let’s get started.

URL matching vs content matching

When we grouped pages manually in part two, we benefited from the fact the URLs groups had clear patterns (collections, products, and the others) but it is often the case where there are no patterns in the URL. For example, Yahoo Stores’ sites use a flat URL structure with no directory paths. Our manual approach wouldn’t work in this case.

Fortunately, it is possible to group pages by their contents because most page templates have different content structures. They serve different user needs, so that needs to be the case.

How can we organize pages by their content? We can use DOM element selectors for this. We will specifically use XPaths.

For example, I can use the presence of a big product image to know the page is a product detail page. I can grab the product image address in the document (its XPath) by right-clicking on it in Chrome and choosing “Inspect,” then right-clicking to copy the XPath.

We can identify other page groups by finding page elements that are unique to them. However, note that while this would allow us to group Yahoo Store-type sites, it would still be a manual process to create the groups.

A scientist’s bottom-up approach

In order to group pages automatically, we need to use a statistical approach. In other words, we need to find patterns in the data that we can use to cluster similar pages together because they share similar statistics. This is a perfect problem for machine learning algorithms.

BloomReach, a digital experience platform vendor, shared their machine learning solution to this problem. To summarize it, they first manually selected cleaned features from the HTML tags like class IDs, CSS style sheet names, and the others. Then, they automatically grouped pages based on the presence and variability of these features. In their tests, they achieved around 90% accuracy, which is pretty good.

When you give problems like this to scientists and engineers with no domain expertise, they will generally come up with complicated, bottom-up solutions. The scientist will say, “Here is the data I have, let me try different computer science ideas I know until I find a good solution.”

One of the reasons I advocate practitioners learn programming is that you can start solving problems using your domain expertise and find shortcuts like the one I will share next.

Hamlet’s observation and a simpler solution

For most ecommerce sites, most page templates include images (and input elements), and those generally change in quantity and size.

I decided to test the quantity and size of images, and the number of input elements as my features set. We were able to achieve 97.5% accuracy in our tests. This is a much simpler and effective approach for this specific problem. All of this is possible because I didn’t start with the data I could access, but with a simpler domain-level observation.

I am not trying to say my approach is superior, as they have tested theirs in millions of pages and I’ve only tested this on a few thousand. My point is that as a practitioner you should learn this stuff so you can contribute your own expertise and creativity.

Now let’s get to the fun part and get to code some machine learning code in Python!

Collecting training data

We need training data to build a model. This training data needs to come pre-labeled with “correct” answers so that the model can learn from the correct answers and make its own predictions on unseen data.

In our case, as discussed above, we’ll use our intuition that most product pages have one or more large images on the page, and most category type pages have many smaller images on the page.

What’s more, product pages typically have more form elements than category pages (for filling in quantity, color, and more).

Unfortunately, crawling a web page for this data requires knowledge of web browser automation, and image manipulation, which are outside the scope of this post. Feel free to study this GitHub gist we put together to learn more.

Here we load the raw data already collected.

Feature engineering

Each row of the form_counts data frame above corresponds to a single URL and provides a count of both form elements, and input elements contained on that page.

Meanwhile, in the img_counts data frame, each row corresponds to a single image from a particular page. Each image has an associated file size, height, and width. Pages are more than likely to have multiple images on each page, and so there are many rows corresponding to each URL.

It is often the case that HTML documents don’t include explicit image dimensions. We are using a little trick to compensate for this. We are capturing the size of the image files, which would be proportional to the multiplication of the width and the length of the images.

We want our image counts and image file sizes to be treated as categorical features, not numerical ones. When a numerical feature, say new visitors, increases it generally implies improvement, but we don’t want bigger images to imply improvement. A common technique to do this is called one-hot encoding.

Most site pages can have an arbitrary number of images. We are going to further process our dataset by bucketing images into 50 groups. This technique is called “binning”.

Here is what our processed data set looks like.

Adding ground truth labels

As we already have correct labels from our manual regex approach, we can use them to create the correct labels to feed the model.

We also need to split our dataset randomly into a training set and a test set. This allows us to train the machine learning model on one set of data, and test it on another set that it’s never seen before. We do this to prevent our model from simply “memorizing” the training data and doing terribly on new, unseen data. You can check it out at the link given below:

Model training and grid search

Finally, the good stuff!

All the steps above, the data collection and preparation, are generally the hardest part to code. The machine learning code is generally quite simple.

We’re using the well-known Scikitlearn python library to train a number of popular models using a bunch of standard hyperparameters (settings for fine-tuning a model). Scikitlearn will run through all of them to find the best one, we simply need to feed in the X variables (our feature engineering parameters above) and the Y variables (the correct labels) to each model, and perform the .fit() function and voila!

Evaluating performance

After running the grid search, we find our winning model to be the Linear SVM (0.974) and Logistic regression (0.968) coming at a close second. Even with such high accuracy, a machine learning model will make mistakes. If it doesn’t make any mistakes, then there is definitely something wrong with the code.

In order to understand where the model performs best and worst, we will use another useful machine learning tool, the confusion matrix.

When looking at a confusion matrix, focus on the diagonal squares. The counts there are correct predictions and the counts outside are failures. In the confusion matrix above we can quickly see that the model does really well-labeling products, but terribly labeling pages that are not product or categories. Intuitively, we can assume that such pages would not have consistent image usage.

Here is the code to put together the confusion matrix:

Finally, here is the code to plot the model evaluation:

Resources to learn more

You might be thinking that this is a lot of work to just tell page groups, and you are right!

Mirko Obkircher commented in my article for part two that there is a much simpler approach, which is to have your client set up a Google Analytics data layer with the page group type. Very smart recommendation, Mirko!

I am using this example for illustration purposes. What if the issue requires a deeper exploratory investigation? If you already started the analysis using Python, your creativity and knowledge are the only limits.

If you want to jump onto the machine learning bandwagon, here are some resources I recommend to learn more:

Attend a Pydata event I got motivated to learn data science after attending the event they host in New York.

Hands-On Introduction To Scikit-learn (sklearn)

Scikit Learn Cheat Sheet

Efficiently Searching Optimal Tuning Parameters

If you are starting from scratch and want to learn fast, I’ve heard good things about Data Camp.

Got any tips or queries? Share it in the comments.

Hamlet Batista is the CEO and founder of RankSense, an agile SEO platform for online retailers and manufacturers. He can be found on Twitter @hamletbatista.

The post Using Python to recover SEO site traffic (Part three) appeared first on Search Engine Watch.

from Digtal Marketing News https://searchenginewatch.com/2019/04/17/using-python-to-recover-seo-site-traffic-part-three/

[igot89bct-blog]

Assessment #2: Reflective journaling

The Creative Technologies experience I chose to apply the “Kolb cycle” to is the very first Introduction to Creative Technologies (ICT) project I was given, a vlog. The vlog was an individual activity where I had to describe my reasons behind my decision to become a Creative Technologist.

I was encouraged to creatively explain why I chose to study at University, why Auckland University of Technology in particular, what Creative Technologies is historically and what I envision this career path to be. Emphasis was also placed on my ideas in the vlog being original, critical, informed and broad.

 This activity is experientially significant as a teaching tool as it teaches students to analyse their own thinking and reasoning towards their choices, helping them define their goals and causes them to research what it takes to achieve them.

The activity helps students understand the ramifications of the choices they’ve taken. It helps them understand their predecessors in that field; and what existing expectations and paradigms are waiting in the industry.

 For myself, the vlog assignment was a steep learning curve. I had never edited before and had to learn how to use new editing software. I had never filmed before, yet alone on a smart phone and I had to learn how to record my voice as its own entity for the narration. The script had to be rewritten many times to express complicated reasoning behind the vlog’s purpose and compressing the various paths in my life to my current decision to study was also difficult.

The vocal recording and editing were particularly difficult as I soon found that pacing for filming and for my narrative reading was of great importance to the flow of the overall vlog. Projection and pronunciation were also unexpected difficulties in the editing and recording process.

Arguably, my difficulties arose due to my self-imposed limit of not wanting to be shown on camera. I had to face my own issues with self esteem and my own short comings as a creator and a person in order to complete the project. In a way, it was like a strange form of therapy – I had to face my own demons around low confidence to create a competent result.

It was a good creative exercise to work around this limit, however, the earlier discussed difficulties around narration and editing were birthed completely from this limit.

In the end, I did not film enough footage to fit with my narration and thus, had to be filmed anyway. The experience taught me to allow myself to be flexible with my limits and allow myself to be vulnerable on camera. It also taught me to approach my projects with a more unbiased view, to see my creations and myself as materials to achieve the desired outcome. It was more important for the points expressed in the narration to have a physical representation of my injury, it had more impact upon the viewer seeing the repercussions than just a disembodied voice speaking about the topic.

 While completing the project I learned about the technical aspects, but I struggled with the academic purpose of why this project was useful to students – why a vlog was our assignment instead of an essay, for instance. To enlighten myself, I researched vlogging and the benefits thoroughly.

In a study of veterans’ vlogging, it was postulated that a therapeutic narrative could be achieved from collective commentary given from any of the community online who have an interest in the subject matter, not just an expert’s opinion as a person would receive from professional therapy (Schuman, Lawrence and Pope, 2019).

The study reported that vloggers were more open to sharing personal information, their faces and even stigmatising conditions in contrast to text-blogs or real life interactions as further reasoning for the deep therapeutic nature of the bond between vlogger and audience. They further postulate that vloggers turned to social media (in this case, Youtube) to process feelings of alienation, grief and loss of self and relationships.

A survey stipulated that vlogs can be used in more ways than text or audioblogs, e.g. in online education, online gaming, product marketing and news reporting (Gao, Tian, Huang and Yang, 2010).

Molyneux, Gibson, Singer and O’Donnell argue that “Vloggers also view vlogs; therefore vloggers engage with videos on several levels – they are both the encoders and the decoders, both producers and members of the audience and the Youtube community”. They emphasise how vlogging is a social activity, encouraging people to view and participate in vlog creation (Molyneux, Gibson, Singer and O’Donnell, 2008).

Vloggers attempting to connect with strangers after a loss of a loved one has been found to happen quickly; months, weeks, even days after the death, and shows that vlogging in a 24/7 online world where someone is ‘always there’ is a comfort (Gibson, 2016).

Gibson emphasises the interactive nature of vlogging, shown by the empathy expressed in comments of the vlogs. These commenters act as a substitute support system despite co-presence to the vlogger’s grief being impossible. Gibson further purports that a support network can be garnered from online communities where real world support is lacking.

An exploration of vlogging explains how vlogging can be a useful tool for identity experimentation for people transitioning genders (Raun, 2015). Raun postulates that vlogging is a continually reforming and changing form of storytelling, with feedback coming from the creator as well as the viewers. He argues that this makes the narrative of the vlogs more non-linear and democratic than written autobiographies.

 After this research, I discovered various benefits to vlogging; it can be empathy from strangers to help with a healing, structured therapeutic narrative, that people are more open with themselves in a vlog than in a blog or in real life interactions, or that vlogging helped them process feelings that they could not in real life.

Vlogging can be more useful than text or audioblogs and connects people socially, through creativity and comforting support. It can help people figure out their identities, it’s as ever-changing as people themselves and can act as a way to monitor their progress, like a visual diary.

 References:

Gibson, M. (2016). Youtube and bereavement vlogging: Emotional exchange between strangers. Journal of Sociology 52(4), 631-645. https://journals-sagepub-com.ezproxy.aut.ac.nz/doi/pdf/10.1177/1440783315573613

Molyneux, H. Gibson, K. Singer, J. O’Donnell, S. (2008). New Visual Media and Gender: A Content, Visual and Audience Analysis of Youtube Vlogs. Conference Papers – International Communication Association Annual Meeting, 1-12. http://web.a.ebscohost.com.ezproxy.aut.ac.nz/ehost/pdfviewer/pdfviewer?vid=5&sid=258c6212-018e-44a9-aa72-65aa55798a79%40sessionmgr4009

Raun, T. (2015). Video blogging as a vehicle of transformation: Exploring the intersection between trans identity and information technology. International Journal of Cultural Studies 18(3), 365-378. https://journals-sagepub-com.ezproxy.aut.ac.nz/doi/pdf/10.1177/1367877913513696

Schuman, D. L. Lawrence, K. A. Pope, N. (2019). Broadcasting War Trauma: An Exploratory Netnography of Veterans’ Youtube Vlogs. Qualitative Health Research 29(3), 357-370. http://dx.doi.org.ezproxy.aut.ac.nz/10.1177/1049732318797623

Wen, G. Yonghong, T. Tiejun, H. Qiang, Y. (2010). Vlogging: A Survey of Videoblogging Technology on the Web. ACM Computing Surveys 42(4), 15:1 – 15:57. http://eds.b.ebscohost.com.ezproxy.aut.ac.nz/eds/pdfviewer/pdfviewer?vid=4&sid=edca290d-1305-4408-bc98-241a4bd5fbc0%40pdc-v-sessmgr05

[magnetictape233-blog]

Not known Details About Magnetic Tape

The specialized handbook for your tape recorder will inform you how. Established the recorder's reproduce electronics output amount to your 0-dB reference within the VTVM. Even though recording at magnetic sheeting , range the frequency of the sign generator from the lowest to optimum frequency you are examining. Ensure that the output volume of the sign generator stays the identical. When you sweep from the frequencies, look at the VTVM. You will see the amplitude increase and slide when you fluctuate the output frequency of your signal generator. While you technique the bottom and the very best frequencies the magnetic tape recorder can successfully file, you will see the VTVM fall to a lot less than - 3 dB. This determines the decreased and upper limits of the frequency-reaction specification for that magnetic tape recorder. 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Precision Linear Stages, or precision motorized linear stages, high precision motorized linear stages, Have Been Ready For Delivery to Germany. You are welcome to visit our download centre to check E-catalogues or watch our video centre to check more projects. https://youtube.com/shorts/zIdeQaMjhes?feature=share Guide rail embedded module (Precision Linear Stages), the new product has been improved on the existing basis in terms of design structure, sliding seat rigidity, sealing and dust prevention. It can be adapted to the mainstream servo and stepping motors in the market. There are more upgradeable models with built-in drive control integration, which meet the more needs of different customers. Guide rail embedded module Rigid lifting of sliding seat: The body and the sliding seat are integrated to improve the poor rigidity of the original sliding seat. Optimized torque characteristics and stronger rigidity: The torque characteristics are greatly enhanced, the load displacement is reduced, and the rigidity is stronger. Installation dimensions are compatible: It can adapt to the general installation dimensions at home and abroad. The installation size of aluminum base and slide can be customized. Full tightness and dust prevention of steel belt: High flexibility steel belt structure, durable. The fully enclosed structure reduces the entry of foreign matters and prevents the internal grease from being thrown out. It can be used in the bad environment of the clean room. Time saving and convenient assembly: The slide cover and coupling cover are designed without screws, which is convenient for disassembly and assembly. The screws can be fixed from top to bottom or from bottom to top without removing the steel belt. The installation datum bearing is added on the side of the body. There is a locating pin hole at the bottom of the body. Suitable for mainstream motor: Suitable for mainstream servo and stepping motor. The motor can be directly connected, installed on the left side, right side and bottom side. External photoelectric sensor. Customers can choose the motor brand according to their own needs. External oiling design: The whole series can be externally oiled, and the screw rod and guide rail can be lubricated at the same time without removing the cover. Embedded guide rail structure: The base and slide of the module are made of aluminum extruded profiles. After the embedded guide rail is grinded, the straightness and rigidity are greatly improved. Drive control integrated module The drive control integrated module, based on the advantages of the guide rail embedded module, integrates the guide rail embedded module, servo motor and drive controller. Small size, high integration and simple wiring simplify the electrical design of customers and meet their more space needs. Low voltage servo drive control integrated system: Support low voltage dc24~48v range. There is no need to configure additional drives and controllers for the drive control integrated device, and you can choose the built-in or external drive control integrated device. It supports EtherCAT, can bus and RS-485 communication. Support external pulse signal, i/o signal 5 in 3 out. Incremental encoder and absolute encoder can be selected. The absolute encoder has a built-in battery, and the origin can be maintained after power failure. Intelligent motion control software: PLC ladder diagram programming and motion control functions can flexibly realize various motion modes without external signals. It has the choice of position mode, speed mode and torque mode. Online real-time monitoring of pulse signals, i/o signals and status information of drive control body machine. Read the full article

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[droneseco]

The JG Maker Artist-D: An IDEX Printer for $389?

JGMaker Artist D

7.00 / 10

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The JGMaker Artist-D is a fully-fledged IDEX printer at less than half the price you'd usually pay for one. Unfortunately, some design issues prevent it from greatness.

Specifications

Brand: JGMaker

Build Volume: 12.2 x 12.2 x 13.8 inches (310 x 310 x 350 mm)

Connectivity: SD Card

Heated Build Plate: Yes

Feed Type: Direct (Dual)

Dimensions: 22 x 25.2 x 24.8 inches (560 x 640 x 630 mm)

Weight: 30lbs. (13.5kg)

Dual-Color Printing: Yes, independent nozzles

Pros

IDEX at this price is incredible

Simple but effective workflow

Cons

Quick-release nozzles cause more problems than they solve

Buy This Product

JGMaker Artist D other

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Budget 3D printers have flooded the market in recent years. Some provide cheap alternatives to mainstream brands. Others put their own spin on the technology.

The JGMaker Artist-D falls into the second camp. It is an Independent Dual Extruder (IDEX) printer capable of large dual color prints and dual printing—simultaneously printing two models.

Launched initially on Kickstarter, the Artist D can currently be ordered directly from JGMaker for just less than $600. Be prepared for a wait though as the first backers still haven't received their units at the time of writing.

With so many underwhelming 3D printers appearing via Kickstarter these days, what does the Artist-D do to stand out?

It turns out, quite a bit.

The JGMaker Artist-D in Brief

The general frame of the Artist-D is similar to most other printers, except for the X-axis belt. Since this is an IDEX printer, two separate belts work independently, moving the direct-drive extruders along linear rails. The Z-axis features dual screws giving a claimed movement accuracy of 0.001mm.

The build area is a generous 310 x 310 x 350 mm, and the composite build plate is removable, attached to the hotbed via magnets in the base. Each extruder/nozzle combination has its own home location with wire cleaning brushes to automatically clear filament from the nozzles, which runs straight from the spools to the extruders via a runout sensor – no clogged Bowden tubes here!

The single-color backlit LCD is controlled via a rotary encoder and uses Marlin Firmware version bugfix 2.0.x. During the Kickstarter, JGMaker revealed a "pro" edition of the Artist-D featuring a color touch screen along with a few upgrades, none of which were present for this review.

The Artist-D can print various materials, including PLA, TPU, PETG, and ABS, along with composites and PVA for soluble support structures.

Extruder system: Direct drive

Print head: Dual Single nozzle

Nozzle size: 0.4 mm

Max. hot end temperature: 245 °C

Max. heated bed temperature: 90 °C

Print bed material: FA platform

Bed leveling: Manual

Connectivity: SD card

Filament sensor: Yes

Filament diameter: 1.75 mm

Third-party filament: Yes

Filament materials: Consumer materials (PLA, ABS, PETG, TPU)

Recommended slicer: Cura

Operating system: Windows 7/10/XP

File types: STL, OBJ, G-code

What Makes IDEX Printers So Special?

Before moving on, a quick primer on the pros and cons of IDEX printing. In short, IDEX printers can give true dual-color printing, with sharp differences between the two colors and no need for the separate tower that dual extruder single nozzle printers need to avoid color blending. On the other hand, color gradient printing is not possible with IDEX printers.

While the two extruders on an IDEX printer are technically independent, this only means independence along the X-axis in most printers. This still allows for some interesting use cases, though. Dual heads can print two identical models simultaneously. If you load both filament spools with the same color, you can print models up to 111 mm wide in batches of two.

Perhaps more exciting to hobby roboticists will be the mirror function. When you are manufacturing symmetrical parts, the ability to load a single model to an SD card and receive two mirrored prints saves time at almost every step.

Artist-D Initial Setup

The setup for the Artist-D is relatively simple. It comes mostly assembled, requiring only the top arch to be attached to the base via four screws. It's a little fiddly to do alone, but even taking my time, the printer was fully assembled within half an hour.

Wiring up the Artist-D is also very easy thanks to the full-color manual and numbered cables/sockets. The flex cables are fairly robust and designed to not get in the way no matter what the printer is doing. Both extruders come with nozzles pre-fitted, but one of the Artist-D's key features is the smart system for fitting and replacing nozzles via a push-button on the side of each hot end housing.

JGMaker provides all the tools required to build and use the Artist-D, and the quality of these tools appears to be a little higher than the average. The wood-handled bed-scraper is a nice touch. The Artist-D also comes with a replacement nozzle and two full small filament rolls, more than the usual "just enough for the test print" amount you get with many other printers.

The print bed has four spring-mounted hand screws for leveling, which uses the primary extruder head nozzle as a reference point. A menu option cycles the nozzle between the center and all four corners for easy leveling – a feature of the Marlin firmware more than anything specific to this printer.

After setting up and leveling, you are ready to start your first print. Feeding in the filament is very simple, after using the Preheat PLA menu setting, feed the filament through the hole in the extruder until it comes out of the nozzle.

Test Prints and Print Modes

JGMaker provides a number of test prints as STLs, along with an Ultimaker Cura installer. The version provided with the Artist-D is a little out of date but functionally identical to recent Cura builds. After following a brief setup (as given in the user manual), you are ready to print.

The way the Artist-D approaches different types of print is quite intuitive. All single and dual-color prints work much as normal within Cura. Whether you are using a single color and extruder or merging two parts of a model and assigning to each extruder, the printer works using its Auto Park feature. This behavior is much like any other 3D printer.

For mirrored and duplicated prints, the manual instructs to simply move the print -80 mm in the X-axis and select the appropriate print type on the printer. Depending on your viewpoint, this could be seen as a good thing, a simple way to allow less computer-savvy people to use these features. Others might miss the ability to specify these things in software and communicate with the printer without relying on an SD card.

My initial test prints went well, with the "money-cat" model coming out perfectly. As with all 3D printers, there was a mixed bag here, and some problems are generic problems that anyone using a 3D printer will be familiar with. Unfortunately, there were some issues that were a little more severe, but we'll come on to those later.

JGMaker also provides a stacked block model for dual-color calibration. After an initial print, you can take manual measurements of the output and use a menu to offset the second extruder.

It seems a primitive way of calibrating something so precise, but then how else can you ensure nothing has slipped during shipping?

Familiar Problems, New Sources

Unfortunately, this is where the problems began. Single color printing worked fine, but duplication and mirror printing mostly didn't come out properly. After a lot of tweaking, it turned out that there was a fundamental height difference between the two nozzles.

This could be fixed by adding a thicker base to whatever model you wanted to duplicate, but then you need to choose between either one nozzle starting touching the build plate or one so high it might not adhere. This wouldn't be an issue if you could manually change the nozzle height, but you can't. The software offset only applies to Auto Park mode, and the clever 'quick release' nozzle system prevents precise height adjustment.

The easy to replace nozzles are a nice idea, though in practice, they are more trouble than they are worth. Early in testing the printer, I decided to swap the nozzles. The media for the Artist-D shows someone simply pressing the button and retrieving the nozzle with their fingers. In reality, it is not so simple.

Quick-Switch Nozzles: Convenience or Liability?

Removing the nozzle first requires freeing it of filament, therefore heating the hot end. You really do not want to try to remove a hot nozzle with your fingers! After clearing the filament, you can press the button and carefully remove the nozzle with pliers.

While still hot, you'll want to clean the extruder area fully, as any leftover filament can stop the nozzle seating properly. There's no tactile feedback when the nozzle is fully in - which is what caused the height discrepancy most likely.

After much testing and cleaning, and several extra nozzles, the main extruder clogged completely while in normal running.

Filament clogging problems are not unique to this printer, but in this case, it seems the cause of them is to do with the combination of directly feeding filament into the nozzle attachment. The clog pushed back from the nozzle right over the top of the hot end casing – something I've never seen happen before.

Build Plate Woes

The build plate itself is a composite material that grips prints very well and can be easily removed. It's flexible too, allowing you to bend it under prints to help loosen them. In fact, most prints ended up leaving residue on the plate, which needed scraping off with the provided scraper. This isn't necessarily a negative, though – I'd rather a too grippy build plate than too smooth.

Both the metal heated plate and the composite cover seem to be of excellent quality, so I was somewhat taken aback when I found it impossible to level the bed properly. The center of the print bed was several millimeters higher than the corners.

Warped print beds are common on cheap 3D printers, and there are various workarounds, but given the perceived quality of most other parts of this printer, it was a disappointment.

JGMaker Artist-D: Almost Great

The JGMaker Artist-D has so much potential. IDEX FDM printers with large build areas represent the best of both worlds – aesthetically pleasing multicolor prints and functional, fast part prototyping.

I don't want to be harsh on the Artist-D, there's clearly a lot of thought that has gone into this printer, and it offers a lot for less than half the cost of similarly specced printers. Unfortunately, the issues it exhibits seem to go beyond the normal quirks and headaches that all 3D printers share, into problems caused specifically by the well-meaning yet poorly implemented nozzle setup.

I'm sure workarounds will come, and this printer will eventually be good, but in its current iteration, the Artist-D is a tough printer to work with.

The JG Maker Artist-D: An IDEX Printer for $389? published first on http://droneseco.tumblr.com/

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